1.to be born with a weak constitution and suffer from ill health during one's life2.(fig.) to be problematic from the start, and get even worse over time
to be the first to worry about affairs of state, and the last to enjoy oneself (quotation from the essay On Yueyang Tower 岳阳楼记[yuè yáng lóu jì] by Song writer Fan Zhongyan 范仲淹[fàn zhòng yān])